1-(2-Hydroxyethyl)piperazine is a chemical compound with the molecular formula C₆H₁₄N₂O. It consists of a piperazine ring (a six-membered ring with two nitrogen atoms at opposite positions) substituted with a 2-hydroxyethyl group (–CH₂CH₂OH) on one of the nitrogen atoms.
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1-(2-Hydroxyethyl)piperazine (CAS 103-76-4, molecular formula C₆H₁₄N₂O) serves as a critical structural building block for complex chemical synthesis. Presenting as a visually clear, colorless or pale yellow liquid, this compound features a distinctive piperazine ring substituted with a 2-hydroxyethyl group on one of the nitrogen atoms. When poured or transferred, it exhibits a smooth, consistent fluid viscosity characteristic of its precise molecular weight of 130.19. The physical profile includes a melting point of -38.5 °C, a boiling point of 246 °C, and a reliable density of 1.061 g/mL at 25 °C. For procurement professionals and formulation chemists requiring exact chemical identifiers, this substance is fully traceable via its standard CAS registry number, alongside detailed SMILES and InChIKey structural representations for accurate database verification and material planning.
Packaged securely in heavy-duty 200-liter iron drums with a net weight of 225kg, this industrial-grade intermediate delivers exceptional reactivity. The dual-functional nature of the molecule—combining the secondary amine of the piperazine ring with the primary alcohol of the hydroxyethyl group—grants it excellent compatibility across diverse pharmaceutical, polymer, and chemical manufacturing processes. The distinct chemical structure allows for precise molecular interactions, ensuring predictable outcomes during demanding synthesis operations.
Achieving a strict industrial and pharmaceutical grade purity of ≥97.0%, this compound undergoes rigorous quality control protocols to eliminate trace impurities that could otherwise interfere with sensitive catalytic reactions. The elevated purity level directly translates to improved reaction yields and fewer unwanted byproducts during complex syntheses. Furthermore, the liquid maintains excellent molecular stability under standard storage environments. With a verified flashing point of >230 °F, facility managers can integrate this material into their production lines with confidence, knowing it meets stringent fire safety and handling criteria.
The unique molecular architecture of 1-(2-Hydroxyethyl)piperazine allows it to perform multiple functional roles across entirely different manufacturing sectors. In the formulation of active pharmaceutical ingredients (APIs), it acts as a highly reactive intermediate, facilitating the creation of specific molecular bonds. For heavy industrial applications, it functions as a highly effective chelating agent and corrosion inhibitor, actively binding with metal ions to protect expensive processing equipment from oxidative degradation. Additionally, polymer manufacturers utilize its reactive sites to modify polymer chains, thereby altering the physical characteristics and reaction kinetics of the final plastic or resin materials.
The stable liquid state of this chemical simplifies the dosing, pumping, and mixing phases of large-scale industrial operations, thereby reducing the mechanical complexity of material transfer. To accommodate different stages of product development, we provide flexible packaging solutions. Whether you require small-scale gram or kilogram quantities for initial laboratory research, or full-scale commercial volumes, the packaging adapts to your specific procurement cycle. The standard bulk configuration utilizes secure 200-liter iron drums, which provide a durable, impact-resistant barrier against external contamination during global transit, ensuring the heavy metallic containers arrive intact.
| Product Name | 1-(2-Hydroxyethyl)piperazine |
| CAS | 103-76-4 |
| MF | C6H14N2O |
| MW | 130.19 |
| Appearance | Colorless or pale yellow liquid |
| Melting Point | -38.5 °C |
| Boiling Point | 246 °C(lit.) |
| Density | 1.061 g/mL at 25 °C(lit.) |
| Flashing Point | >230 °F |
Package:
It is packed in 200 liter iron drum, net weight 225kg. We also offer highly flexible packaging options ranging from small laboratory-grade containers for research and development purposes to bulk industrial drums, ensuring exact alignment with your current production scale and material handling requirements.
Storage:
Please store in a cool, ventilated place. Keep containers tightly sealed to prevent moisture ingress and maintain the structural integrity of the chemical over its specified shelf life.
Within pharmaceutical synthesis, the dual reactivity of the hydroxyl and piperazine groups makes this compound an indispensable intermediate. It is frequently deployed in the multi-step synthesis of complex antihistamines, targeted antibiotics, and other specialized therapeutic agents. The precise molecular geometry assists chemists in achieving desired stereochemical outcomes. Simultaneously, in the industrial sector, this compound is formulated into advanced metalworking fluids and protective industrial coatings. Upon application, it forms a microscopic protective barrier on metal surfaces, effectively neutralizing corrosive agents and extending the operational lifespan of critical machinery under harsh environmental conditions.
Polymer engineers rely on 1-(2-Hydroxyethyl)piperazine as a highly efficient chain extender and cross-linking agent during the production of advanced polyurethanes and epoxy resins. By integrating into the polymer matrix, it significantly enhances the tensile strength, thermal resistance, and overall mechanical durability of the finished goods. In broader chemical processing and commercial water treatment facilities, it serves as a potent chelating agent. It actively binds and isolates problematic metal ions suspended in solutions, thereby preventing unwanted catalytic reactions, reducing mineral scale buildup, and vastly improving the overall efficiency of the fluid system.
Superior Purity Assurance & Quality Control: Our 1-(2-Hydroxyethyl)piperazine undergoes rigorous analytical testing to guarantee a high purity of ≥97.0%. This strict quality control framework minimizes impurity interference, ensuring your chemical reactions proceed with maximum yield and predictability, meeting both pharmaceutical and industrial standards.
Reliable Supply Capacity & Inventory: We maintain a highly organized inventory system with strategic local and overseas warehousing capabilities. Our stable production capacity ensures rapid response times, facilitating on-time delivery and consistent supply chains for large-volume bulk contracts.
Comprehensive Compliance & Documentation: Transparency is central to our operations. We provide complete, readily accessible technical documentation, including detailed Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS). This ensures your procurement process remains fully compliant with global safety and environmental regulations.
Expert Technical Support: Beyond material supply, our dedicated team of chemical specialists offers professional guidance on optimal product usage, safe storage protocols, and application optimization, helping you maximize the efficiency of the chemical in your specific manufacturing environment.
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